Mesothelioma and Work Exposure Mesothelioma is more common for those who work with asbestos. Firefighters, construction workers and military veterans are at a higher risk. The lung's lining (pleural mesothelioma) or the abdomen, is the most common mesothelioma site. In rare instances, it may affect the testicles or the heart. https://vimeo.com/703524243