In mild of such observations, sirtuins are recognised as novel regulators of immuno-metabolism in human beings. Apart from SIRT1, SIRT2 has long been lately linked to cytoskeleton remodeling and activation of NLRP3 in intracellular pathways[117]. Other than the activation of innate immunity, the contribution of adaptive immune cells in inducing https://www.directivepublications.org/journal-of-diabetology-research/